What are TRK inhibitors?
Larotrectinib and entrectinib are first-generation TRK inhibitors and have demonstrated rapid and durable responses and favourable safety profiles in patients with TRK fusion-positive cancers.
What kind of mutation is NTRK?
A mutation (change) that occurs when a piece of the chromosome containing a gene called NTRK breaks off and joins with a gene on another chromosome. NTRK gene fusions lead to abnormal proteins called TRK fusion proteins, which may cause cancer cells to grow.
What does NTRK stand for?
Neurotrophic tyrosine receptor kinase (NTRK) gene fusions are an actionable biomarker for cancer therapy and can be found in over 25 different types of cancer, regardless of where they are located in the body.
What is the Met gene?
A gene that makes a protein that is involved in sending signals within cells and in cell growth and survival. Mutated (changed) forms of the MET gene may cause abnormal cells to grow and spread in the body.
Is larotrectinib chemotherapy?
VITRAKVI® is an oral medicine that is not a chemotherapy.
What is Repotrectinib?
Repotrectinib (repotrectinib, TPX-0005) is an orally-available multi-kinase inhibitor designed to overcome resistance due to solvent-front substitutions involving TRKA, TRKB, and TRKC proteins as well as those involving ROS1, and ALK [1, 2].
What does NTRK gene do?
The NTRK1 gene provides instructions for making a protein that is essential for the development and survival of nerve cells (neurons), especially those that transmit information about sensations such as pain, temperature, and touch (sensory neurons).
What is NTRK testing?
What is NTRK testing? NTRK testing through next generation sequencing enables the detection of NTRK fusions in the NTRK1, NTRK2, and NTRK3 genes, which can help patients determine their likely response if considering treatment with TRK inhibitors.
Is Larotrectinib chemotherapy?
What is Pan TRK?
Pan-Trk IHC is a time-efficient and tissue-efficient screen for NTRK fusions, particularly in driver-negative advanced malignancies and potential cases of secretory carcinoma and congenital fibrosarcoma. Pan-Trk IHC can help determine whether translation occurs for novel NTRK rearrangements.
What does C in c-Met stand for?
c-Met (mesenchymal-epithelial transition factor), which belongs to the MET family, along with RON, is a type of receptor tyrosine kinase that is expressed on the surfaces of various epithelial cells; its ligand is HGF/SF(ligand hepatocyte growth factor/scatter factor) [1, 2].
Is c-Met receptor integral?
c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene….C-Met.
MET | ||
---|---|---|
Species | Human | Mouse |
Entrez | 4233 | 17295 |
Ensembl | ENSG00000105976 | ENSMUSG00000009376 |
UniProt | P08581 | P16056 |