What does resistin hormone do?
Resistin is a cysteine-rich hormone secreted from white adipocytes. Resistin is involved in insulin resistance and links obesity to diabetes in mice; it is involved in inflammation in humans. Resistin is exclusively expressed in white adipose tissue in rodents.
What happens when adipose tissue is damaged?
More commonly, too much adipose tissue leads to obesity, mainly from too much visceral fat. Obesity leads to a number of serious health problems. Obesity increases the risk of developing type 2 diabetes as it causes the body to become resistant to insulin.
What causes adipose tissue dysfunction?
The majority of patients with obesity have an impaired adipose tissue function caused by the interaction of genetic and environmental factors which lead to adipocyte hypertrophy, hypoxia, a variety of stresses and inflammatory processes within adipose tissue.
What is adipose tissue dysfunction?
Dysfunction of adipose tissue can result in insulin resistance and its metabolic complications in patients with excess body fat (obesity) or markedly reduced body fat (lipodystrophy). Alterations in free fatty acid and adipocytokine release from adipose tissue may underlie metabolic complications.
What is serum resistin?
The data demonstrate that resistin protein is present in human adipose tissue and blood, and that there is significantly more resistin in the serum of obese subjects. Serum resistin is not a significant predictor of insulin resistance in humans.
What type of protein is resistin associated with?
Serum resistin is associated with C-reactive protein & LDL cholesterol in type 2 diabetes and coronary artery disease in a Saudi population. Cardiovasc Diabetol.
What is adipose?
Adipose tissue, also known as fat tissue or fatty tissue, is a connective tissue that is mainly composed of fat cells called adipocytes. Adipocytes are energy storing cells that contain large globules of fat known as lipid droplets surrounded by a structural network of fibers.
What is the function of adipose tissue in subcutaneous tissue?
Adipose tissue is a loose connective tissue mostly composed of adipocytes and plays a major role in storage of energy in the form of lipids. Adipose fat also serves as an important cushion and insulates the body from heat and cold.
What is the function of adipose tissue?
The adipose tissue is a critical regulator of systemic energy homeostasis by acting as a caloric reservoir. In excess nutrient conditions, the adipose tissue stores surplus nutrients in the form of neutral lipids, whereas in nutrient deficit conditions, it supplies nutrients to other tissues through lipolysis (1).
How does diabetes affect adipose tissue?
Type 2 diabetes mellitus Chronic inflammation in adipose tissue, liver, and skeletal muscle provoke insulin resistance and at the islet, provokes beta cell dysfunction. It is the combination of insulin resistance and beta cell dysfunction that characterizes DM.
Does adipose tissue cause insulin resistance?
Enlarged adipocytes display insulin resistance without much macrophage infiltration into adipose tissue following a short-term high-fat diet [32▪]. Thus, even without inflammatory responses, excess lipid in adipose cells results in insulin resistance.
Is resistin a peptide hormone?
Resistin is a cysteine-rich peptide hormone that was isolated from adipose tissues and that has been found to link obesity to type II diabetes in rodents. The name resistin stands for “resistance to insulin” because it reduces the sensitivity of target tissues to insulin.