What medications cause agranulocytosis?
Drugs that can cause agranulocytosis include:
- antithyroid medications, such as carbimazole and methimazole (Tapazole)
- anti-inflammatory medications, such as sulfasalazine (Azulfidine), dipyrone (Metamizole), and nonsteroidal anti-inflammatory drugs (NSAIDs)
- antipsychotics, such as clozapine (Clozaril)
How quickly does agranulocytosis occur?
Agranulocytosis usually develops in the first 3 months after ATD therapy is initiated [10], but cases after 5 days up to more than 10 years of exposure have also been described [22].
Is agranulocytosis reversible?
Agranulocytosis is treatable with medication, but the outlook varies from person to person. Adults over 65 are more likely to experience complications such as sepsis. Agranulocytosis can cause severe problems in people who have other health conditions, such as kidney disease, heart disease or breathing problems.
How does Carbimazole cause agranulocytosis?
Carbimazole-induced agranulocytosis occurs generally within few weeks or months of taking the anti-thyroid medication, but onset may be delayed by 1 year with an incidence of 0.1%–0.3%. Agranulocytosis is a serious rare side effect of carbimazole….
| Article Access Statistics | |
|---|---|
| Viewed | 7038 |
| Comments | [Add] |
Does PTU cause agranulocytosis?
Background: Propylthiouracil (PTU) has been in use for more than half a century for the treatment of hyperthyroidism. While it is largely known to cause agranulocytosis, its association with aplastic anemia is generally unheard of.
Which anti thyroid drug causes agranulocytosis?
Propylthiouracil is used to treat hyperthyroidism, especially in women during pregnancy. Agranulocytosis: a marked decrease in the white blood cell count that causes a patient to be more likely to develop an infection. This is commonly associated with a fever and/or a sore throat.
Does methimazole cause neutropenia?
Methimazole-induced neutropenia leads to gingival ulceration and necrosis along with systemic symptoms such as fever and sore throat in some patients. The first step to recovery includes early confirmation of methimazole’s effect and early discontinuation of the drug.
Does methimazole cause agranulocytosis?
Agranulocytosis is a rare and serious adverse effect of antithyroid drugs (ATD), in particular methimazole (MMI), and usually develops within 3 months following the start of uninterrupted ATD treatment.
How do you know if you have agranulocytosis?
Signs and symptoms of agranulocytosis include fever, chills, weakness, sore throat, sores in the mouth or throat, bleeding gums, bone pain, low blood pressure, fast heartbeat, and trouble breathing.
Which of the following drugs has the highest risk of agranulocytosis?
The drug most strongly associated with a risk of agranulocytosis was ticlopidine hydrochloride with an odds ratio (OR) of 103.23 (95% confidence interval [CI], 12.73-837.44), followed by calcium dobesilate (OR, 77.84 [95% CI, 4.50-1346.20]), antithyroid drugs (OR, 52.75 [95% CI, 5.82-478.03]), dipyrone (metamizole …
How do you treat agranulocytosis?
The treatment of acquired agranulocytosis includes the identification and elimination of drugs or other agents that induce this disorder. Antibiotic medications may also be prescribed if there is a positive blood culture for the presence of bacteria or if a significant local infection develops.
What are the adverse effects of propylthiouracil?
Propylthiouracil may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- hair loss.
- difficulty tasting food.
- numbness, burning, or tingling of the hands or feet.
- joint or muscle pain.
- dizziness.
- swelling of the neck.